One-hit knockout moves (Japanese: 一撃必殺わざ, Hepburn: one-hit knockout move) are moves that are guaranteed to faint the target in one hit. Numerous Pokémon can learn them. A prerequisite to the success of this move is that the attacker must be equal to or higher than the level of the opposing Pokémon. One-hit KO moves have the lowest accuracy in the game. Using a Focus Sash or a Pokémon with the Sturdy ability will prevent fainting.
List of One-Hit Knockout moves
Fissure
Pokémon that can learn Fissure via Level-Up
Diglett, Dugtrio, Camerupt, Trapinch, Barboach, Whiscash, Groudon, Wormadam (Sandy Cloak), Hippopotas, and Hippowdon.
Pokémon that can learn Fissure via Breeding
Lapras, Snorlax, Swinub, Piloswine, Phanpy, Donphan, Wailmer, Wailord, Torkoal, Spheal, Sealeo, Walrein, Shieldon, Bastiodon, Shellos, Gastrodon, and Mamoswine.
Guillotine
Pokémon that can learn Guillotine via Level-Up
Krabby, Kingler, Pinsir, Gligar, Corphish, Crawdaunt, Gliscor, Haxorus, Pawniard and Bisharp.
Horn Drill
Pokémon that can learn Horn Drill via Level-Up
Nidoran, Nidorino, Rhyhorn, Rhydon, Goldeen, Seaking,Rhyperior, and Excadrill.
Pokémon that can learn Horn Drill via Breeding
Ponyta, Rapidash, Seel, Dewgong, and Lapras.
Sheer Cold
Pokémon that can learn Sheer Cold via Level-Up
Dewgong, Lapras, Articuno, Glalie, Spheal, Sealeo, Walrein, Kyogre, Snover, Abomasnow, and Cryogonal.